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CS-W001157 4
Total: USD 88.00

4-Bromo-6-methyl-1H-indole

  • CAS No. 885520-48-9

  • Cat. No. CS-W022113
  • Purity≥98%
  • MDL No.MFCD07781547

*For research and further manufacturing use only, not for direct human use.

4-Bromo-6-methyl-1H-indole|CS-W022113

Structure of 885520-48-9

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General Information

  • CAS No. 885520-48-9
  • Cat. No. CS-W022113
  • Purity ≥98%
  • MDL No. MFCD07781547
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈BrN
  • Molecular Weight 210.07
  • Synonym(s) None
  • SMILES CC1=CC2=C(C(Br)=C1)C=CN2

Description

4-Bromo-6-methyl-1H-indole is a sterically hindered indole derivative featuring a bromine atom at the 4-position and a methyl group at the 6-position, enhancing its stability and reactivity profile. This substitution pattern enables direct incorporation into complex heterocyclic architectures via palladium-catalyzed cross-coupling reactions, offering efficient access to functionalized indole scaffolds for medicinal chemistry applications.

Application

4-Bromo-6-methyl-1H-indole serves as a versatile building block in medicinal chemistry and materials science, enabling efficient access to substituted indole scaffolds via Pd-catalyzed cross-coupling reactions. The bromine at C4 provides a reliable site for Suzuki, Stille, or Negishi coupling, while the methyl group at C6 enhances electron density and modulates reactivity. Its bench-stable nature and compatibility with diverse functional groups make it well-suited for modular synthesis of bioactive molecules and heterocyclic frameworks.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   3.23882
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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