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Structure of 88625-24-5
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5-Chloropyrazine-2-carbaldehyde is a heteroaromatic aldehyde featuring a chlorine substituent at the 5-position and a formyl group at the 2-position of the pyrazine ring. This electron-deficient scaffold serves as a key building block in medicinal chemistry, enabling direct coupling reactions via its reactive carbonyl functionality. The molecule exhibits enhanced stability under standard bench conditions and integrates efficiently into diverse synthetic sequences, including transition-metal-catalyzed cross-couplings and nucleophilic additions.
5-Chloropyrazine-2-carbaldehyde serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds via nucleophilic addition and transition-metal-catalyzed coupling reactions. Its electrophilic aldehyde group exhibits compatibility with diverse functional groups, while the chloro substituent supports further derivatization through palladium-catalyzed cross-coupling. The compound demonstrates bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: