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Structure of 886363-40-2
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1-Ethynyl-2-(trifluoromethoxy)benzene features a terminal alkyne paired with a strongly electron-withdrawing trifluoromethoxy group, enabling efficient copper-catalyzed coupling reactions. The molecule exhibits excellent stability under standard conditions and integrates readily into complex molecular architectures via click chemistry.
1-Ethynyl-2-(trifluoromethoxy)benzene serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to conjugated arylalkynes. Its trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the terminal alkyne functionality facilitates Sonogashira, Glaser, and Hiyama couplings. The compound exhibits excellent bench stability and is compatible with a broad range of functional groups, making it well-suited for the synthesis of advanced pharmaceutical intermediates and functional materials.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H227-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: