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Structure of 886498-89-1
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This trifluoromethoxy-substituted benzoic acid features a fluorine atom at the meta position and a strongly electron-withdrawing trifluoromethoxy group at the para position, delivering enhanced acidity and metabolic stability. The resulting electronic effects facilitate efficient coupling in pharmaceutical synthesis and enable selective derivatization under standard conditions.
3-Fluoro-4-(trifluoromethoxy)benzoic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical scaffolds. Its orthogonal functional groups—fluorine, trifluoromethoxy, and carboxylic acid—offer enhanced metabolic stability and modulated lipophilicity. The compound exhibits good bench stability, facilitates straightforward derivatization via amide or ester formation, and is compatible with standard coupling reactions, making it a practical choice for lead optimization and API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: