1-Chloro-2,3-difluorobenzene

Name: 1-Chloro-2,3-difluorobenzene
Brand: ChemScene
Availability: InStock
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CAS No. 36556-47-5
Cat. No. CS-W021314
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 36556-47-5

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Description

1-Chloro-2,3-difluorobenzene is a fluorinated aromatic compound featuring ortho-fluorine and chlorine substituents on a benzene ring. This configuration imparts enhanced metabolic stability and electron-deficient character, enabling efficient incorporation into pharmaceutical intermediates and agrochemical scaffolds via palladium-catalyzed cross-coupling reactions. The molecule exhibits favorable solubility in common organic solvents and maintains stability under standard bench conditions.

Application

1-Chloro-2,3-difluorobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The ortho-fluorine substituents enhance metabolic stability and modulate electronic properties, while the chloro group provides a reliable handle for selective functionalization. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for iterative synthesis of complex heterocyclic scaffolds and pharmaceutical intermediates.

General Information

CAS No. 36556-47-5
Cat. No. CS-W021314
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃ClF₂
Molecular Weight 148.54
Synonym(s) 2,3-Difluorochlorobenzene
SMILES FC1=C(F)C(Cl)=CC=C1

Computational Chemistry Data

TPSA 0
LogP 2.6182
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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1-Chloro-2,3-difluorobenzene

CAS No. 36556-47-5

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