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CS-W001157 4
Total: USD 88.00

6-bromoisoquinolin-3-amine

  • CAS No. 891785-28-7

  • Cat. No. CS-W001039
  • Purity≥96%
  • MDL No.MFCD11101002
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-bromoisoquinolin-3-amine|CS-W001039

Structure of 891785-28-7

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Description

6-Bromoisoquinolin-3-amine features a brominated isoquinoline core with a strategically positioned amine group, enabling direct functionalization in cross-coupling and C–H amination reactions. This electron-deficient heterocycle delivers high reactivity under palladium catalysis, facilitating efficient access to complex pharmaceutical intermediates. The bromo substituent serves as a reliable handle for further diversification, while the amine moiety enhances solubility and binding affinity in target-directed synthesis.

Application

6-Bromoisoquinolin-3-amine serves as a versatile building block for the synthesis of isoquinoline-based pharmaceuticals and functional materials. The bromine at the 6-position enables palladium-catalyzed cross-coupling reactions, while the primary amine at the 3-position offers a handle for derivatization via acylation, alkylation, or reductive amination. Its bench-stable solid form facilitates handling and purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development.

General Information

  • CAS No. 891785-28-7
  • Cat. No. CS-W001039
  • Purity ≥96%
  • MDL No. MFCD11101002
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇BrN₂
  • Molecular Weight 223.07
  • Synonym(s) 6-Bromoisoquinolin-3-amine, 3-Amino-6-bromo-2-azanaphthalene
  • SMILES Nc1cc2cc(Br)ccc2cn1

Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.5795
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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