Lot numbers can be found on the outside label of a product:
2,6-Dichloroisonicotinamide
-
CAS No. 89281-13-0
- Cat. No. CS-0151393
- Purity≥98%
- MDL No.MFCD00052640
*For research and further manufacturing use only, not for direct human use.
Structure of 89281-13-0
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 89281-13-0
- Cat. No. CS-0151393
- Purity ≥98%
- MDL No. MFCD00052640
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₄Cl₂N₂O
- Molecular Weight 191.01
- Synonym(s) 2,6-Dichloropyridine-4-carboxamide, 4-Carbamoyl-2,6-dichloropyridine
- SMILES ClC1=CC(C(N)=O)=CC(Cl)=N1
Description
2,6-Dichloroisonicotinamide features a pyridine core with strategically positioned chlorine atoms at the 2 and 6 positions, enhancing electrophilicity at the carbonyl carbon. This electron-deficient scaffold facilitates direct incorporation into heterocyclic systems, serving as a key intermediate in medicinal chemistry for targeted kinase inhibitors and bioactive compound synthesis under standard conditions.
Application
2,6-Dichloroisonicotinamide serves as a versatile building block in medicinal chemistry, enabling the construction of heterocyclic scaffolds through direct coupling and functionalization. Its ortho-chlorine substituents facilitate palladium-catalyzed cross-coupling reactions, while the amide group provides hydrogen-bonding capability and metabolic stability. The compound exhibits excellent bench stability and is compatible with standard purification protocols, making it well-suited for iterative synthesis campaigns in API development.
Synthesis
-
Route1
-
In-stock
98027-84-0 -
3019-71-4 - ~63%
-
In-stock
89281-13-0
References
-
Schade, Matthias A.; Manolikakes, Georg; Knochel, Paul Organic Letters, 2010 , vol. 12, # 16 p. 3648 - 3650
-
-
Route2
-
101990-72-1
-
1450-14-2
- ~%
-
In-stock
89281-13-0
References
-
US5049569 A1, ;
-
-
Route3
-
In-stock
5398-44-7 - ~%
-
In-stock
89281-13-0
References
-
Recueil des Travaux Chimiques des Pays-Bas, , vol. 48, p. 468,471
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H332-H335
|
|
|
Precautionary Statements : P261-P302+P352-P304+P340
|
|
Quality Control
Computational Chemistry Data
- TPSA 55.98
- LogP 1.4873
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 2,6-Dichloroisonicotinamide sigma2,6-Dichloroisonicotinamide manufacturer2,6-Dichloroisonicotinamide price2,6-Dichloroisonicotinamide structure2,6-Dichloroisonicotinamide SDSbuy 2,6-Dichloroisonicotinamide2,6-Dichloroisonicotinamide supplier2,6-Dichloroisonicotinamide uses2,6-Dichloroisonicotinamide molecular weightprice of 2,6-Dichloroisonicotinamide2,6-Dichloroisonicotinamide chemical name formula of 2,6-Dichloroisonicotinamide