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CS-W001157 4
Total: USD 88.00

4-Hydroxynicotinonitrile

  • CAS No. 89324-16-3

  • Cat. No. CS-0147706
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Hydroxynicotinonitrile|CS-0147706

Structure of 89324-16-3

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General Information

  • CAS No. 89324-16-3
  • Cat. No. CS-0147706
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄N₂O
  • Molecular Weight 120.11
  • Synonym(s) 3-pyridinecarbonitrile, 1,4-dihydro-4-oxo-
  • SMILES N#CC1=CN=CC=C1O

Description

4-Hydroxynicotinonitrile features a pyridine core bearing both hydroxyl and nitrile groups at para positions, enabling dual functionalization in synthetic pathways. This electron-deficient heterocycle integrates readily into bioactive scaffolds and serves as a key intermediate in pharmaceutical synthesis under standard conditions.

Application

4-Hydroxynicotinonitrile serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through nucleophilic substitution and condensation reactions. Its dual functionality—hydroxyl and nitrile groups—facilitates downstream derivatization, including ring formation and bioisosteric replacement, with excellent bench stability and straightforward purification.

Safety Information

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GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P264-P270-P330-P405-P501

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Computational Chemistry Data

  • TPSA   56.91
  • LogP   0.65888
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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