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CS-W001157 4
Total: USD 88.00

5-Bromo-2,3-difluoropyridine

  • CAS No. 89402-44-8

  • Cat. No. CS-W003324
  • Molecule weight193.98
  • Purity≥98%
  • MDL No.MFCD06659525

*For research and further manufacturing use only, not for direct human use.

5-Bromo-2,3-difluoropyridine|CS-W003324

Structure of 89402-44-8

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General Information

  • CAS No. 89402-44-8
  • Cat. No. CS-W003324
  • Purity ≥98%
  • MDL No. MFCD06659525
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₂BrF₂N
  • Molecular Weight 193.98
  • Synonym(s) 3-DIFLUOROPYRIDINE
  • SMILES Brc1cnc(c(c1)F)F

Description

5-Bromo-2,3-difluoropyridine is a fluorinated heterocyclic building block featuring a bromine substituent at the 5-position and fluorine atoms at adjacent 2- and 3-positions. This electron-deficient pyridine scaffold enables efficient coupling in cross-coupling reactions, particularly in palladium-catalyzed processes. The strategic halogen placement enhances reactivity while maintaining stability under standard reaction conditions.

Application

5-Bromo-2,3-difluoropyridine serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. Its orthogonal halogenation pattern enables selective functionalization via palladium-catalyzed couplings, while the fluorine atoms enhance metabolic stability and modulate electronic properties. The compound exhibits excellent bench stability and compatibility with standard reaction conditions, facilitating efficient synthesis of complex heterocyclic scaffolds and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.1223
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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