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Structure of 894796-87-3
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Methyl 4-amino-2-(trifluoromethyl)benzoate features a trifluoromethyl group that imparts enhanced electron-withdrawal and metabolic stability, while the amino substituent enables direct functionalization. This scaffold integrates readily into pharmaceutical intermediates and bioactive molecule libraries, offering high reactivity under standard coupling conditions and excellent solubility in common organic solvents.
Methyl 4-amino-2-(trifluoromethyl)benzoate serves as a versatile building block in medicinal chemistry, enabling direct access to bioactive heterocycles and functionalized aromatic scaffolds. Its ortho-trifluoromethyl group enhances metabolic stability and modulates electronic properties, while the methyl ester and primary amine functionalities offer orthogonal reactivity for coupling, amidation, and cyclization reactions. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for scalable synthesis and iterative library development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: