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CS-W001157 4
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Methyl 2-amino-3-hydroxy-2-methylpropanoate hydrochloride

  • CAS No. 89500-37-8

  • Cat. No. CS-0112989
  • Molecule weight169.61
  • Purity≥97%
  • MDL No.MFCD28400767

*For research and further manufacturing use only, not for direct human use.

Methyl 2-amino-3-hydroxy-2-methylpropanoate hydrochloride|CS-0112989

Structure of 89500-37-8

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General Information

  • CAS No. 89500-37-8
  • Cat. No. CS-0112989
  • Purity ≥97%
  • MDL No. MFCD28400767
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNO₃
  • Molecular Weight 169.61
  • Synonym(s) H-2-Me-DL-Ser-OMe.HCl
  • SMILES NC(CO)(C)C(OC)=O.[H]Cl

Description

Methyl 2-amino-3-hydroxy-2-methylpropanoate hydrochloride is a bench-stable, moisture-tolerant amino acid derivative featuring a tertiary alcohol and protected amine functionality. This zwitterionic salt integrates readily into peptide-like scaffolds and serves as a key intermediate in the synthesis of bioactive heterocycles and chiral building blocks under standard conditions.

Application

Methyl 2-amino-3-hydroxy-2-methylpropanoate hydrochloride serves as a valuable building block in the synthesis of β-amino alcohols and heterocyclic scaffolds. Its pendant amino and hydroxyl groups enable straightforward derivatization via alkylation, acylation, or cyclization reactions. The hydrochloride salt enhances bench stability and facilitates purification, while the methyl ester group supports subsequent transformations under standard conditions. This compound functions effectively in peptide-like motifs and medicinal chemistry libraries.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   72.55
  • LogP   -0.7091
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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