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Structure of 89581-38-4
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Methyl 5-bromopyrimidine-2-carboxyate features a bromine substituent at the 5-position and a methyl ester group at the 2-position of a pyrimidine core. This electron-deficient heterocycle serves as a key building block for medicinal chemistry, enabling direct functionalization via palladium-catalyzed cross-coupling reactions. The molecule exhibits robust stability under standard bench conditions and integrates readily into complex molecular architectures.
Methyl 5-bromopyrimidine-2-carboxyate serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions at the C5 position. The bromine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, while the ester group offers compatibility with base-sensitive transformations. Its bench-stable nature and ease of purification facilitate integration into multi-step synthetic sequences for pharmaceutical intermediates and agrochemical scaffolds.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: