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Structure of 455-88-9
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5-Nitro-2-fluorotoluene features a fluorine atom ortho to the methyl group and a nitro group para to it, creating a uniquely activated aromatic system. This electronic asymmetry enables selective coupling reactions in pharmaceutical synthesis. The molecule exhibits enhanced reactivity in palladium-catalyzed cross-coupling processes due to the combined electron-withdrawing effects of the nitro and fluoro substituents. Its bench-stable nature supports reliable handling under standard conditions.
5-Nitro-2-fluorotoluene serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the electron-deficient aromatic ring. Its ortho-fluoro and meta-nitro substituents provide complementary reactivity for palladium-catalyzed cross-coupling and site-selective transformations. The compound exhibits excellent bench stability and facilitates efficient synthesis of heterocyclic scaffolds and fluorinated API intermediates through established synthetic protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302+H312+H332-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: