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Structure of 89641-80-5
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Tetrahydro-2H-pyran-4-yl carbonochloridate serves as a robust, moisture-tolerant carbamoylating agent, enabling efficient coupling of amines under mild conditions. The tetrahydropyran protecting group enhances solubility and stability, while the chloroformate moiety delivers high reactivity for amide bond formation. This reagent streamlines synthetic workflows in peptide and small-molecule chemistry.
Tetrahydro-2H-pyran-4-yl carbonochloridate serves as a stable, bench-friendly carbamoylating agent that facilitates efficient amide bond formation under mild conditions. Its tetrahydropyranyl (THP) protecting group offers orthogonal stability to common functional groups and can be selectively removed post-coupling. This reagent enables reliable derivatization of amines and alcohols with high yield and minimal side reactions, making it well-suited for peptide synthesis, medicinal chemistry intermediates, and modular scaffold construction.
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GHS Pictogram :
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GHS No : GHS02,GHS05,GHS06,GHS08
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Signal Word : Danger
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UN#: 3277
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Class : 6.1 (8)
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Packing Group : Ⅱ
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Hazard Statements : H226-H302-H317-H318-H331-H373
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Precautionary Statements : P210-P240-P241-P242-P243-P260-P264-P270-P271-P272-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P330-P363-P370+P378-P403+P233-P403+P235-P405-P501
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Lot numbers can be found on the outside label of a product: