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CS-W001157 4
Total: USD 88.00

Tetrahydro-2H-pyran-4-yl carbonochloridate

  • CAS No. 89641-80-5

  • Cat. No. CS-0696240
  • Molecule weight164.59
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Tetrahydro-2H-pyran-4-yl carbonochloridate|CS-0696240

Structure of 89641-80-5

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General Information

  • CAS No. 89641-80-5
  • Cat. No. CS-0696240
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₉ClO₃
  • Molecular Weight 164.59
  • Synonym(s) None
  • SMILES ClC(=O)OC1CCOCC1

Description

Tetrahydro-2H-pyran-4-yl carbonochloridate serves as a robust, moisture-tolerant carbamoylating agent, enabling efficient coupling of amines under mild conditions. The tetrahydropyran protecting group enhances solubility and stability, while the chloroformate moiety delivers high reactivity for amide bond formation. This reagent streamlines synthetic workflows in peptide and small-molecule chemistry.

Application

Tetrahydro-2H-pyran-4-yl carbonochloridate serves as a stable, bench-friendly carbamoylating agent that facilitates efficient amide bond formation under mild conditions. Its tetrahydropyranyl (THP) protecting group offers orthogonal stability to common functional groups and can be selectively removed post-coupling. This reagent enables reliable derivatization of amines and alcohols with high yield and minimal side reactions, making it well-suited for peptide synthesis, medicinal chemistry intermediates, and modular scaffold construction.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05,GHS06,GHS08
Signal Word : Danger
UN#: 3277
Class : 6.1 (8)
Packing Group : Ⅱ
Hazard Statements : H226-H302-H317-H318-H331-H373
Precautionary Statements : P210-P240-P241-P242-P243-P260-P264-P270-P271-P272-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P330-P363-P370+P378-P403+P233-P403+P235-P405-P501

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Computational Chemistry Data

  • TPSA   N/A
  • LogP   N/A
  • H_Acceptors   N/A
  • H_Donors   N/A
  • Rotatable_Bonds   N/A

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