2-Methoxy-6-methylpyridin-4-amine

Name: 2-Methoxy-6-methylpyridin-4-amine
Brand: ChemScene
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CAS No. 89943-09-9
Cat. No. CS-0097970
Molecule weight138.17
Purity≥97%
MDL No.MFCD15529703

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-Methoxy-6-methylpyridin-4-amine|CS-0097970

Structure of 89943-09-9

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General Information

CAS No. 89943-09-9
Cat. No. CS-0097970
Purity ≥97%
MDL No. MFCD15529703
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₀N₂O
Molecular Weight 138.17
Synonym(s) 2-Methoxy-6-methyl-4-pyridinamine
SMILES NC1=CC(OC)=NC(C)=C1

Description

2-Methoxy-6-methylpyridin-4-amine features a pyridine core functionalized with methoxy and methyl groups at the 2- and 6-positions, respectively, and a primary amine at the 4-position. This electron-rich scaffold enables direct incorporation into diverse synthetic routes, particularly in medicinal chemistry and catalyst design. The compound exhibits enhanced solubility and stability under standard conditions, facilitating efficient coupling reactions and modular derivatization.

Application

2-Methoxy-6-methylpyridin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds via standard coupling and functionalization reactions. Its ortho-substituted structure provides enhanced metabolic stability and tunable solubility, while the amine functionality facilitates rapid derivatization. Bench-stable and readily purified, it functions effectively in Suzuki-Miyaura couplings, reductive aminations, and transition-metal-catalyzed transformations.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 48.14
LogP 0.98082
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Methoxy-6-methylpyridin-4-amine

CAS No. 89943-09-9

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