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CS-W001157 4
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5-Ethoxypyridin-2-amine

  • CAS No. 89943-11-3

  • Cat. No. CS-W022370
  • Purity≥98%
  • MDL No.MFCD11135752

*For research and further manufacturing use only, not for direct human use.

5-Ethoxypyridin-2-amine|CS-W022370

Structure of 89943-11-3

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General Information

  • CAS No. 89943-11-3
  • Cat. No. CS-W022370
  • Purity ≥98%
  • MDL No. MFCD11135752
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂O
  • Molecular Weight 138.17
  • Synonym(s) 5-Ethoxy-2-pyridinamine
  • SMILES NC1=NC=C(OCC)C=C1

Description

5-Ethoxypyridin-2-amine features a pyridine core functionalized with an ethoxy group at the 5-position and a primary amine at the 2-position. This electron-rich heterocycle integrates readily into synthetic routes requiring polar, bench-stable nitrogen donors. The para-oriented amine enables straightforward derivatization for pharmaceutical intermediates and ligand design.

Application

5-Ethoxypyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the construction of pyridine-based scaffolds through standard coupling and functionalization reactions. Its ethoxy group enhances solubility and modulates electronic properties, while the primary amine facilitates derivatization via acylation, alkylation, or transition-metal-catalyzed cross-coupling. The compound exhibits bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1
    • 2-Bromo-3-Ethoxy-6-nitropyridine|CS-0767406
      137347-01-4
    • ~94%
    • In-stock
      5-Ethoxypyridin-2-amine|CS-W022370
      89943-11-3

    References

    • Piotrowski, David W.; Rogers, Bruce N.; McWhorter JR., William W.; Walker, Daniel Patrick; Corbett, Jeffrey W.; Groppi JR., Vincent E.; Rudmann, Daniel G. Patent: US2003/236287 A1, 2003 ; Location in patent: Page 40 ; US 20030236287 A1
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 81, p. 6049,6053
  • Route3
    • null|null
      35771-41-6
    • ~%
    • In-stock
      5-Ethoxypyridin-2-amine|CS-W022370
      89943-11-3

    References

    • Journal of the American Chemical Society, , vol. 81, p. 6049,6053

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.14
  • LogP   1.0625
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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