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CS-W001157 4
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4,6-Dimethoxypyridin-3-amine

  • CAS No. 89943-34-0

  • Cat. No. CS-0100549
  • Purity≥97%
  • MDL No.MFCD09027594

*For research and further manufacturing use only, not for direct human use.

4,6-Dimethoxypyridin-3-amine|CS-0100549

Structure of 89943-34-0

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General Information

  • CAS No. 89943-34-0
  • Cat. No. CS-0100549
  • Purity ≥97%
  • MDL No. MFCD09027594
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₀N₂O₂
  • Molecular Weight 154.17
  • Synonym(s) 3-PyridinaMine,4,6-diMethoxy
  • SMILES NC1=C(OC)C=C(OC)N=C1

Description

4,6-Dimethoxypyridin-3-amine features two methoxy groups flanking a primary amine on a pyridine core, conferring enhanced solubility and electronic modulation. This electron-rich scaffold serves as a pivotal building block in medicinal chemistry, enabling efficient coupling reactions under mild conditions. The ortho-dimethoxy arrangement provides steric protection to the amine, improving stability during synthesis and purification workflows.

Application

4,6-Dimethoxypyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds via palladium-catalyzed cross-coupling and nucleophilic aromatic substitution. The ortho-dimethoxy pattern enhances solubility and facilitates directed metalation, while the primary amine group supports straightforward derivatization. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for iterative synthesis of bioactive heterocycles and API intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   57.37
  • LogP   0.681
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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