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Structure of 911112-05-5
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5-Iodo-3-(trifluoromethyl)pyridin-2-amine features a reactive iodine handle at the 5-position paired with an electron-deficient trifluoromethyl group, enabling efficient cross-coupling transformations. The pyridin-2-amine scaffold provides a rigid, polar platform for modular assembly in medicinal chemistry and materials science applications.
5-Iodo-3-(trifluoromethyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry and cross-coupling methodologies. The iodide moiety enables reliable Suzuki, Stille, and Buchwald-Hartwig coupling reactions, while the trifluoromethyl group enhances metabolic stability and lipophilicity. The pyridine nitrogen provides coordination capability and improves solubility. This compound exhibits excellent bench stability and is readily purified by flash chromatography, facilitating integration into multi-step synthetic sequences for targeted heterocyclic scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: