Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

di-tert-Butyl (S)-5-oxopyrrolidine-1,2-dicarboxylate

  • CAS No. 91229-91-3

  • Cat. No. CS-0046809
  • Molecule weight285.34
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

di-tert-Butyl (S)-5-oxopyrrolidine-1,2-dicarboxylate|CS-0046809

Structure of 91229-91-3

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 91229-91-3
  • Cat. No. CS-0046809
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₂₃NO₅
  • Molecular Weight 285.34
  • Synonym(s) tert-Butyl N-Boc-L-pyroglutamate
  • SMILES O=C(N([C@H](C(OC(C)(C)C)=O)CC1)C1=O)OC(C)(C)C

Description

di-tert-Butyl (S)-5-oxopyrrolidine-1,2-dicarboxylate features a chiral pyrrolidinone core with two sterically shielded tert-butyl esters, enhancing stability and solubility in organic solvents. This bench-stable derivative enables efficient access to enantioselective synthesis of bioactive lactams and serves as a key intermediate in asymmetric catalysis workflows.

Application

di-tert-Butyl (S)-5-oxopyrrolidine-1,2-dicarboxylate serves as a stable, bench-ready chiral synthon for the construction of pyrrolidine-based scaffolds. The protected lactam moiety enables selective nucleophilic ring opening and facilitates asymmetric synthesis via controlled functionalization. Its tert-butyl esters offer enhanced solubility and ease of purification, while maintaining high stereochemical integrity during downstream transformations. Functions effectively in amine coupling, reductive amination, and transition-metal-catalyzed cross-coupling protocols.

Synthesis

  • Route1

    References

    • Tetrahedron Letters, , vol. 49, # 12 p. 1957 - 1960
  • Route2

    References

    • Tetrahedron, , vol. 69, # 33 p. 6821 - 6825
  • Route3

    References

    • Tetrahedron, , vol. 60, # 45 p. 10277 - 10284

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   72.91
  • LogP   2.2542
  • H_Acceptors   5
  • H_Donors   0
  • Rotatable_Bonds   1

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 91229-91-3 sigma91229-91-3 manufacturer91229-91-3 price91229-91-3 structure91229-91-3 SDSbuy 91229-91-391229-91-3 supplier91229-91-3 uses91229-91-3 molecular weightprice of 91229-91-391229-91-3 chemical name formula of 91229-91-3
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label