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CS-W001157 4
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(6-(Trifluoromethyl)pyridin-2-yl)methanamine

  • CAS No. 916304-19-3

  • Cat. No. CS-0091494
  • Molecule weight176.14
  • Purity≥95%
  • MDL No.MFCD10696232

*For research and further manufacturing use only, not for direct human use.

(6-(Trifluoromethyl)pyridin-2-yl)methanamine|CS-0091494

Structure of 916304-19-3

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General Information

  • CAS No. 916304-19-3
  • Cat. No. CS-0091494
  • Purity ≥95%
  • MDL No. MFCD10696232
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇F₃N₂
  • Molecular Weight 176.14
  • Synonym(s) 6-(TRIFLUOROMETHYL)PYRIDINE-2-METHYLAMINE
  • SMILES NCC1=NC(C(F)(F)F)=CC=C1

Description

This trifluoromethyl-substituted pyridylmethanamine features a polar, electron-deficient pyridine ring paired with a primary amine handle, enabling straightforward functionalization. The para-trifluoromethyl group enhances metabolic stability and modulates electronic properties, making it valuable in medicinal chemistry and catalyst design.

Application

(6-(Trifluoromethyl)pyridin-2-yl)methanamine serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its trifluoromethyl group enhances metabolic stability and modulates electronic properties, while the primary amine facilitates conjugation with carboxylic acids, aldehydes, and electrophiles. The compound exhibits good bench stability, ease of purification, and compatibility with common protecting group strategies, making it a reliable scaffold for API development and lead optimization.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.5591
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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