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CS-W001157 4
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2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol

  • CAS No. 917397-93-4

  • Cat. No. CS-0197508
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol|CS-0197508

Structure of 917397-93-4

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General Information

  • CAS No. 917397-93-4
  • Cat. No. CS-0197508
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₅H₂₃BO₃
  • Molecular Weight 262.15
  • Synonym(s) 2-[4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propan-2-ol
  • SMILES CC(O)(C1=CC=C(B2OC(C)(C)C(C)(C)O2)C=C1)C

Description

This boronate-functionalized tertiary alcohol integrates seamlessly into Suzuki-Miyaura coupling workflows. The tetramethylboronate moiety enables efficient cross-coupling under mild conditions, while the sterically shielded tertiary alcohol imparts enhanced stability and solubility in polar solvents.

Application

2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)propan-2-ol serves as a robust boronate building block for Suzuki-Miyaura cross-coupling reactions. Its sterically hindered tertiary alcohol group enhances bench stability and minimizes protodeboronation, while the tetramethylboronate moiety enables efficient coupling with aryl halides under mild conditions. This compound functions reliably in the construction of biaryl scaffolds common in pharmaceutical and materials chemistry, offering excellent functional group tolerance and straightforward purification.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.69
  • LogP   2.2132
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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