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Structure of 919338-66-2
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This chiral bisphosphine ligand features two electron-rich, sterically shielded phosphorus centers flanked by dimethoxybiphenyl backbones, enabling robust coordination to transition metals in asymmetric catalysis. The bulky diisopropyl and dimethylamino substituents enhance solubility and prevent catalyst deactivation, while the (S)-configuration ensures high enantioselectivity in cross-coupling and hydrogenation reactions under standard conditions.
(S)-(6,6'-Dimethoxybiphenyl-2,2'-diyl)bis{bis[3,5-diisopropyl-4-(dimethylamino)phenyl]phosphine} is a sterically demanding, chiral bisphosphine ligand that enables high-selectivity palladium-catalyzed cross-coupling reactions. Its electron-rich dimethylamino groups and bulky diisopropyl substituents enhance catalyst stability and turnover in Suzuki-Miyaura and Negishi couplings. The ligand exhibits excellent bench stability, facilitates efficient metal loading reduction, and supports the formation of complex biaryl scaffolds with minimal byproduct formation.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: