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1-(6-Methylpyridin-3-yl)ethanamine

  • CAS No. 92295-43-7

  • Cat. No. CS-0197513
  • Molecule weight136.19
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(6-Methylpyridin-3-yl)ethanamine|CS-0197513

Structure of 92295-43-7

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General Information

  • CAS No. 92295-43-7
  • Cat. No. CS-0197513
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₂N₂
  • Molecular Weight 136.19
  • Synonym(s) 1-(6-methyl-3-pyridinyl)ethanamine
  • SMILES CC1=NC=C(C=C1)C(C)N

Description

1-(6-Methylpyridin-3-yl)ethanamine features a pyridine core with a methyl group at the 6-position and an ethylamine side chain at the 3-position, delivering a robust, electron-rich heteroaromatic scaffold. This configuration enhances solubility in polar solvents and supports straightforward functionalization in synthetic transformations. The molecule exhibits bench-stable behavior under standard conditions and integrates readily into ligand design for catalysis or medicinal chemistry applications.

Application

1-(6-Methylpyridin-3-yl)ethanamine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-containing scaffolds through standard amine functionalization. Its ortho-substituted pyridine core provides enhanced metabolic stability and favorable binding interactions. The primary amine facilitates conjugate addition, reductive amination, and coupling reactions, while the methyl group supports site-specific derivatization. Bench-stable and readily purified, it functions effectively in both small-molecule synthesis and process development workflows.

Synthesis

  • Route1

    References

    • ELI LILLY AND COMPANY Patent: WO2008/144222 A2, 2008 ; Location in patent: Page/Page column 17 ;

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.40972
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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