N,N-Dimethylazetidine-3-carboxamide hydrochloride

Name: N,N-Dimethylazetidine-3-carboxamide hydrochloride
Brand: ChemScene
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CAS No. 927390-60-1
Cat. No. CS-0048831
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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N,N-Dimethylazetidine-3-carboxamide hydrochloride|CS-0048831

Structure of 927390-60-1

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General Information

CAS No. 927390-60-1
Cat. No. CS-0048831
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₃ClN₂O
Molecular Weight 164.63
Synonym(s) 3-Azetidinecarboxamide, N,N-dimethyl-, hydrochloride
SMILES Cl.CN(C)C(=O)C1CNC1

Description

N,N-Dimethylazetidine-3-carboxamide hydrochloride features a constrained azetidine ring with dual N-methyl substitutions, enhancing metabolic stability and solubility. The carboxamide functionality provides a hydrogen-bonding handle for molecular recognition, while the hydrochloride salt ensures excellent crystallinity and shelf stability under ambient conditions.

Application

N,N-Dimethylazetidine-3-carboxamide hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to constrained amide-containing scaffolds. Its azetidine core provides enhanced metabolic stability and improved membrane permeability compared to larger heterocycles. The dimethylamino group enhances solubility and facilitates downstream functionalization, while the carboxamide functionality supports diverse coupling reactions. Bench-stable and readily purified, it functions effectively in standard peptide and small-molecule synthesis workflows.

Synthesis

Route1
- 1046469-16-2
- ~%
- In-stock
  
  927390-60-1
References
- JAPAN TOBACCO INC. Patent: US2010/240634 A1, 2010 ; Location in patent: Page/Page column 73 ;
Route2
- 927390-59-8
- ~%
- In-stock
  
  927390-60-1
References
- DAIICHI PHARMACEUTICAL CO., LTD. Patent: WO2007/20936 A1, 2007 ; Location in patent: Page/Page column 176-177 ; WO 2007/020936 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 32.34
LogP -0.2842
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Key Words

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N,N-Dimethylazetidine-3-carboxamide hydrochloride

CAS No. 927390-60-1

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