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Structure of 929000-62-4
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1-Bromo-2-methyl-4-(trifluoromethyl)benzene features a bromine atom positioned ortho to a methyl group and para to a trifluoromethyl substituent, creating a uniquely electron-deficient aromatic scaffold. This configuration enables efficient coupling in palladium-catalyzed cross-coupling reactions, offering high reactivity with minimal side-product formation under standard conditions. The molecule exhibits excellent bench stability and moisture tolerance, simplifying handling in synthetic workflows.
1-Bromo-2-methyl-4-(trifluoromethyl)benzene serves as a versatile building block in cross-coupling chemistry, enabling efficient access to substituted biaryls via palladium-catalyzed reactions. The bromo group exhibits high reactivity in Suzuki, Stille, and Negishi couplings, while the trifluoromethyl and methyl substituents provide enhanced metabolic stability and modulated electronic properties. Bench-stable and compatible with standard purification protocols, it facilitates streamlined synthesis of advanced pharmaceutical intermediates and functional materials.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: