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CS-W001157 4
Total: USD 88.00

4-Amino-2,6-dichloronicotinic acid

  • CAS No. 929288-22-2

  • Cat. No. CS-W022067
  • Purity≥98%
  • MDL No.MFCD19105212
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Amino-2,6-dichloronicotinic acid|CS-W022067

Structure of 929288-22-2

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Description

4-Amino-2,6-dichloronicotinic acid features a conjugated pyridine core bearing two chlorine substituents and a primary amine group, enabling direct integration into diverse heterocyclic scaffolds. This electron-deficient framework supports efficient coupling reactions under mild conditions, offering enhanced solubility in polar solvents and stability during synthetic manipulations.

Application

4-Amino-2,6-dichloronicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its orthogonal functional groups—amino and carboxylic acid—facilitate efficient derivatization via amide coupling, amidation, or electrophilic substitution. The dichloro substitution pattern enhances reactivity in cross-coupling processes and supports structural diversification for target-focused libraries. Bench-stable and readily purified by crystallization, it functions reliably in standard synthetic workflows.

General Information

  • CAS No. 929288-22-2
  • Cat. No. CS-W022067
  • Purity ≥98%
  • MDL No. MFCD19105212
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄Cl₂N₂O₂
  • Molecular Weight 207.01
  • Synonym(s) 4-amino-2,6-dichloronicotinic acid hydrochloride
  • SMILES O=C(O)C1=C(Cl)N=C(Cl)C=C1N

Computational Chemistry Data

  • TPSA   76.21
  • LogP   1.6688
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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