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CS-W001157 4
Total: USD 88.00

6-Chloro-2-methylpyrimidine-4,5-diamine

  • CAS No. 933-80-2

  • Cat. No. CS-0045785
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-methylpyrimidine-4,5-diamine|CS-0045785

Structure of 933-80-2

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Description

6-Chloro-2-methylpyrimidine-4,5-diamine features a pyrimidine core bearing chlorine and methyl substituents at the 6- and 2-positions, respectively, with diamine functionality at C4 and C5. This electron-deficient heterocycle integrates readily into medicinal chemistry scaffolds, serving as a key building block for kinase inhibitors and antiviral agents. The molecule exhibits favorable reactivity under standard coupling conditions and demonstrates stability in common organic solvents.

Application

6-Chloro-2-methylpyrimidine-4,5-diamine serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyrimidine-based scaffolds common in medicinal chemistry. The chloro group facilitates palladium-catalyzed cross-coupling reactions, while the diamine functionality supports derivatization via alkylation, acylation, or cyclization. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for iterative synthesis workflows and API intermediate development.

General Information

  • CAS No. 933-80-2
  • Cat. No. CS-0045785
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇ClN₄
  • Molecular Weight 158.59
  • Synonym(s) 6-chloro-4,5-diamino-2-methylpyrimidine
  • SMILES NC1=NC(C)=NC(Cl)=C1N

Computational Chemistry Data

  • TPSA   77.82
  • LogP   0.60282
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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