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CS-W001157 4
Total: USD 88.00

Iodo-PEG3-N3

  • CAS No. 936917-36-1

  • Cat. No. CS-0108847
  • Purity≥97%
  • MDL No.MFCD25969270

*For research and further manufacturing use only, not for direct human use.

Iodo-PEG3-N3|CS-0108847

Structure of 936917-36-1

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General Information

  • CAS No. 936917-36-1
  • Cat. No. CS-0108847
  • Purity ≥97%
  • MDL No. MFCD25969270
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆IN₃O₃
  • Molecular Weight 329.14
  • Synonym(s) Iodo-PEG4-N3
  • SMILES ICCOCCOCCOCCN=[N+]=[N-]

Description

Iodo-PEG3-N3 is a trifunctional linker featuring a reactive iodide handle, a three-ethylene glycol spacer, and a terminal azide group. This combination enables efficient conjugation in bioorthogonal reactions, with the PEG3 segment enhancing solubility and reducing non-specific binding. Ideal for site-specific labeling in protein and biomolecule engineering workflows under standard conditions.

Application

Iodo-PEG3-N₃ serves as a versatile bifunctional linker for bioconjugation and click chemistry applications. The iodide group enables site-specific alkylation of nucleophilic residues (e.g., cysteine) in proteins or peptides, while the terminal azide facilitates highly selective copper-catalyzed or strain-promoted cycloadditions. Its PEG3 spacer provides solubility and reduced aggregation, enhancing performance in aqueous environments. This reagent is bench-stable, easily purified by chromatography, and widely used in the construction of antibody-drug conjugates, peptide-protein hybrids, and functionalized surfaces.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   76.45
  • LogP   1.7815
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   11

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