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Structure of 944328-72-7
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4,4-Difluorobutanoic acid features a fluorinated aliphatic chain with two electronegative fluorine atoms at the terminal carbon, enhancing metabolic stability and lipophilicity. This configuration imparts unique electronic and steric properties, enabling its use in bioactive molecule design, particularly as a metabolically resistant analog in medicinal chemistry applications.
4,4-Difluorobutanoic acid serves as a valuable building block in medicinal chemistry, enabling the introduction of a metabolically stable, electron-withdrawing difluoromethylene unit adjacent to a carboxylic acid. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient incorporation into bioactive molecules. The gem-difluoro motif enhances lipophilicity and modulates pKa, offering improved metabolic resistance in drug candidates.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3265
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H227-H314
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Precautionary Statements : P210-P260-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501
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Lot numbers can be found on the outside label of a product: