5-Bromo-4-(trifluoromethyl)pyridin-2-amine

Name: 5-Bromo-4-(trifluoromethyl)pyridin-2-amine
Brand: ChemScene
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CAS No. 944401-56-3
Cat. No. CS-M0294
Purity≥95%
MDL No.MFCD09864896

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FedEx Limited Quantities Ground	$0.00
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5-Bromo-4-(trifluoromethyl)pyridin-2-amine|CS-M0294

Structure of 944401-56-3

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Description

5-Bromo-4-(trifluoromethyl)pyridin-2-amine features a bromine atom at the 5-position and a trifluoromethyl group at the 4-position of the pyridine ring, creating a highly electron-deficient heterocyclic scaffold. This configuration enables efficient cross-coupling reactions in medicinal chemistry and materials synthesis. The amine functionality provides a reactive handle for further derivatization under mild conditions.

Application

5-Bromo-4-(trifluoromethyl)pyridin-2-amine serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. The bromo group enables palladium-catalyzed coupling with boronic acids, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity. Its pyridine amine functionality provides a handle for further derivatization, including amidation or electrophilic substitution. The compound exhibits good bench stability and facilitates efficient purification, making it well-suited for iterative synthesis of complex heterocyclic scaffolds.

General Information

CAS No. 944401-56-3
Cat. No. CS-M0294
Purity ≥95%
MDL No. MFCD09864896
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄BrF₃N₂
Molecular Weight 241.01
Synonym(s) 2-amino-5-bromo-4-(trifluoromethyl)pyridine
SMILES FC(F)(F)C1=C(Br)C=NC(N)=C1

Computational Chemistry Data

TPSA 38.91
LogP 2.4451
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H319
Precautionary Statements : P264-P270-P280-P330-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Bromo-4-(trifluoromethyl)pyridin-2-amine

CAS No. 944401-56-3

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