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CS-W001157 4
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4-Methyl-1,4-azaphosphinane 4-oxide hydrochloride

  • CAS No. 945459-80-3

  • Cat. No. CS-0132047
  • Purity≥95%
  • MDL No.MFCD30730725

*For research and further manufacturing use only, not for direct human use.

4-Methyl-1,4-azaphosphinane 4-oxide hydrochloride|CS-0132047

Structure of 945459-80-3

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General Information

  • CAS No. 945459-80-3
  • Cat. No. CS-0132047
  • Purity ≥95%
  • MDL No. MFCD30730725
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₃ClNOP
  • Molecular Weight 169.59
  • Synonym(s) 4-methyl-1,4lambda5-azaphosphinan-4-one hydrochloride
  • SMILES CP1(CCNCC1)=O.[H]Cl

Description

4-Methyl-1,4-azaphosphinane 4-oxide hydrochloride delivers a stable, moisture-tolerant phosphine oxide scaffold with enhanced solubility in polar solvents. This bench-stable derivative features a tertiary phosphine oxide functionality flanked by a methyl-substituted azaphosphinane ring, enabling efficient coupling reactions and coordination chemistry applications.

Application

4-Methyl-1,4-azaphosphinane 4-oxide hydrochloride serves as a stable, bench-ready phosphine oxide scaffold with predictable reactivity in transition-metal-catalyzed transformations. Its tertiary phosphine oxide functionality enables effective ligand design in palladium and nickel catalysis, while the methyl substituent enhances solubility and reduces oxidation susceptibility. This compound facilitates reliable coupling reactions and functions as a key building block in the synthesis of bioactive heterocycles and pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H350
Precautionary Statements : P264-P270-P280-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   1.0043
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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