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CS-W001157 4
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2-Bromoaniline hydrochloride

  • CAS No. 94718-79-3

  • Cat. No. CS-0321666
  • Purity≥98%
  • MDL No.MFCD00060215

*For research and further manufacturing use only, not for direct human use.

2-Bromoaniline hydrochloride|CS-0321666

Structure of 94718-79-3

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General Information

  • CAS No. 94718-79-3
  • Cat. No. CS-0321666
  • Purity ≥98%
  • MDL No. MFCD00060215
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇BrClN
  • Molecular Weight 208.48
  • Synonym(s) 2-Bromophenylhydrazine hydrochloride HCl
  • SMILES C1=CC=C(C(=C1)Br)N.Cl

Description

2-Bromoaniline hydrochloride offers a moisture-tolerant, bench-stable platform for constructing brominated aromatic scaffolds. The protonated amine enhances solubility in polar solvents, enabling seamless integration into coupling reactions and electrophilic substitution workflows. This salt form simplifies handling while preserving reactivity for downstream synthetic applications.

Application

2-Bromoaniline hydrochloride serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of brominated aromatic amines into complex scaffolds. Its bench-stable form facilitates handling and purification, while the anilino functionality supports diverse coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig transformations. The hydrochloride salt enhances solubility in polar solvents and improves crystallinity, streamlining isolation and storage.

Synthesis

  • Route1
    • null|null
      577-19-5
    • ~64%
    • In-stock
      2-Bromoaniline hydrochloride|CS-0321666
      94718-79-3

    References

    • Pehlivan, Leyla; Metay, Estelle; Laval, Stephane; Dayoub, Wissam; Demonchaux, Patrice; Mignani, Gerard; Lemaire, Marc Tetrahedron, 2011 , vol. 67, # 10 p. 1971 - 1976
  • Route2
    • null|null
      615-36-1
    • ~%
    • In-stock
      2-Bromoaniline hydrochloride|CS-0321666
      94718-79-3

    References

    • Attrell, Robert J.; Widdifield, Cory M.; Korobkov, Ilia; Bryce, David L. Crystal Growth and Design, 2012 , vol. 12, # 3 p. 1641 - 1653

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P362-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.4531
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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