Lot numbers can be found on the outside label of a product:
1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid
-
CAS No. 952182-02-4
- Cat. No. CS-W021332
- Purity≥98%
- MDL No.MFCD09832891
*For research and further manufacturing use only, not for direct human use.
![1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid|CS-W021332](https://file.chemscene.com/productPIC/CS-W021332.gif)
Structure of 952182-02-4
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 952182-02-4
- Cat. No. CS-W021332
- Purity ≥98%
- MDL No. MFCD09832891
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₅N₃O₂
- Molecular Weight 163.13
- Synonym(s) 1H-pyrazolo[3,4-b] pyridine-5-carboxylic acid
- SMILES OC(=O)C1=CC2=C(NN=C2)N=C1
Description
1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid features a fused heterocyclic core with a carboxylic acid group at the 5-position, enabling direct conjugation or derivatization. This scaffold integrates rigid, electron-deficient aromaticity with a polar functional handle, enhancing solubility and enabling precise molecular positioning in medicinal chemistry and materials science applications.
Application
1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and materials science. Its rigid fused scaffold exhibits excellent stability and functional group tolerance, enabling direct derivatization via amide coupling, esterification, or metal-catalyzed cross-coupling reactions. The carboxylic acid moiety facilitates conjugation with biomolecules and supports purification by standard chromatographic techniques. This compound functions as a key intermediate in the synthesis of kinase inhibitors and other bioactive scaffolds.
Synthesis
-
Route1
-
1086423-59-7 - ~77%
-
In-stock
952182-02-4
References
-
GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling Patent: WO2013/127268 A1, 2013 ; Location in patent: Page/Page column 61; 62; 63 ;
-
-
Route2
-
In-stock
![Ethyl 4-hydroxy-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate|CS-0096774](https://file.chemscene.com/productPIC/CS-0096774.gif)
227617-15-4 - ~%
-
In-stock
952182-02-4
References
-
WO2013/127266 A1, ;
-
-
Route3
-
In-stock
![Ethyl 4-chloro-1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate|CS-0096795](https://file.chemscene.com/productPIC/CS-0096795.gif)
227617-16-5 - ~%
-
In-stock
952182-02-4
References
-
WO2013/127266 A1, ;
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H319
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 78.87
- LogP 0.6561
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 952182-02-4 sigma952182-02-4 manufacturer952182-02-4 price952182-02-4 structure952182-02-4 SDSbuy 952182-02-4952182-02-4 supplier952182-02-4 uses952182-02-4 molecular weightprice of 952182-02-4952182-02-4 chemical name formula of 952182-02-4