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CS-W001157 4
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(1-Ethyl-1H-indazol-5-yl)boronic acid

  • CAS No. 952319-70-9

  • Cat. No. CS-0054318
  • Molecule weight190.01
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(1-Ethyl-1H-indazol-5-yl)boronic acid|CS-0054318

Structure of 952319-70-9

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General Information

  • CAS No. 952319-70-9
  • Cat. No. CS-0054318
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁BN₂O₂
  • Molecular Weight 190.01
  • Synonym(s) B-(1-Ethyl-1H-indazol-5-yl)boronic acid
  • SMILES CCN1N=CC2=C1C=CC(B(O)O)=C2

Description

This boronate moiety integrates readily into Suzuki-Miyaura cross-coupling reactions under standard conditions, delivering biaryl architectures with high functional group tolerance. The indazolyl scaffold imparts stability and enhanced solubility in polar solvents, facilitating efficient reaction progress in complex synthesis workflows.

Application

(1-Ethyl-1H-indazol-5-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. Its boronic acid functionality exhibits good bench stability and tolerates a range of functional groups, facilitating direct incorporation into complex molecular architectures. The indazolyl core provides a rigid, polar scaffold with established utility in medicinal chemistry and materials science.

Synthesis

  • Route1

    References

    • BIOENERGENIX; MCCALL, John M.; ROMERO, Donna L.; KELLY, Robert C. Patent: WO2012/119046 A2, 2012 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.28
  • LogP   -0.264
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   2

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