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Structure of 953039-10-6
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2-Chloroquinazolin-8-ol is a bench-stable heterocyclic scaffold featuring a chlorine substituent at the 2-position and a phenolic hydroxyl group at C8. This configuration enables direct functionalization in medicinal chemistry, particularly in kinase inhibitor development and fluorescent probe design. The molecule integrates readily into bioactive frameworks due to its planar structure and hydrogen-bonding capacity.
2-Chloroquinazolin-8-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to quinazoline-based scaffolds through nucleophilic substitution and coupling reactions. Its chloro group at the C2 position provides high reactivity for transition-metal-catalyzed transformations, while the phenolic hydroxyl at C8 offers orthogonal functionality for derivatization. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns targeting kinase inhibitors and other bioactive heterocycles.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H311-H331
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501
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Lot numbers can be found on the outside label of a product: