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CS-W001157 4
Total: USD 88.00

2-Chloroquinazolin-8-ol

  • CAS No. 953039-10-6

  • Cat. No. CS-0045100
  • Molecule weight180.59
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Chloroquinazolin-8-ol|CS-0045100

Structure of 953039-10-6

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General Information

  • CAS No. 953039-10-6
  • Cat. No. CS-0045100
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅ClN₂O
  • Molecular Weight 180.59
  • Synonym(s) 2-chloro-quinazolin-8-ol
  • SMILES OC1=CC=CC2=CN=C(Cl)N=C12

Description

2-Chloroquinazolin-8-ol is a bench-stable heterocyclic scaffold featuring a chlorine substituent at the 2-position and a phenolic hydroxyl group at C8. This configuration enables direct functionalization in medicinal chemistry, particularly in kinase inhibitor development and fluorescent probe design. The molecule integrates readily into bioactive frameworks due to its planar structure and hydrogen-bonding capacity.

Application

2-Chloroquinazolin-8-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to quinazoline-based scaffolds through nucleophilic substitution and coupling reactions. Its chloro group at the C2 position provides high reactivity for transition-metal-catalyzed transformations, while the phenolic hydroxyl at C8 offers orthogonal functionality for derivatization. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns targeting kinase inhibitors and other bioactive heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H311-H331
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P405-P501

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Computational Chemistry Data

  • TPSA   46.01
  • LogP   1.9888
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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