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CS-W001157 4
Total: USD 88.00

7-Formylbenzofuran

  • CAS No. 95333-14-5

  • Cat. No. CS-0040167
  • Purity≥96%
  • MDL No.MFCD08272125

*For research and further manufacturing use only, not for direct human use.

7-Formylbenzofuran|CS-0040167

Structure of 95333-14-5

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General Information

  • CAS No. 95333-14-5
  • Cat. No. CS-0040167
  • Purity ≥96%
  • MDL No. MFCD08272125
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆O₂
  • Molecular Weight 146.14
  • Synonym(s) Benzofuran-7-carbaldehyde
  • SMILES O=CC1=C(OC=C2)C2=CC=C1

Description

7-Formylbenzofuran delivers a reactive aldehyde handle at the 7-position of a benzofuran scaffold, enabling direct conjugation in synthetic transformations. This electron-deficient heterocycle integrates readily into modular synthesis workflows, offering high stability under standard conditions and compatibility with diverse functional groups.

Application

7-Formylbenzofuran serves as a versatile building block in synthetic organic chemistry, enabling direct functionalization at the benzofuran core through electrophilic and nucleophilic transformations. The aldehyde group facilitates reductive amination, cyanation, and transition-metal-catalyzed coupling reactions, while the fused heterocyclic framework provides structural rigidity and metabolic stability. Its bench-stable nature and compatibility with common protecting groups support efficient synthesis of complex scaffolds for medicinal chemistry and materials applications.

Synthesis

  • Route1
    • null|null
      68-12-2
    • In-stock
      7-Bromobenzofuran|CS-W019960
      133720-60-2
    • ~85%
    • In-stock
      7-Formylbenzofuran|CS-0040167
      95333-14-5

    References

    • Ajinomoto Co., Inc. Patent: EP1878734 A1, 2008 ; Location in patent: Page/Page column 13 ;
  • Route2
    • 7-Benzofuranmethanol|CS-0050110
      209256-55-3
    • ~78%
    • In-stock
      7-Formylbenzofuran|CS-0040167
      95333-14-5

    References

    • Bristol-Myers Squibb Company Patent: EP1027043 B1, 2004 ; Location in patent: Page/Page column 19 ;
  • Route3
    • null|null
      60-29-7
    • null|null
      84-58-2
    • In-stock
      2,3-Dihydrobenzofuran-7-carbaldehyde|CS-W005801
      196799-45-8
    • ~22%
    • In-stock
      7-Formylbenzofuran|CS-0040167
      95333-14-5

    References

    • Synthelabo Patent: US6063810 A1, 2000 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   30.21
  • LogP   2.2453
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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