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Structure of 95758-92-2
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This diazirine derivative features a trifluoromethyl group and an iodomethyl substituent on the aromatic ring, enabling efficient photoaffinity labeling. The electron-withdrawing trifluoromethyl moiety enhances stability and reactivity under UV activation, while the iodomethyl handle facilitates site-specific conjugation. Bench-stable and moisture-tolerant, it integrates seamlessly into probe design for target identification in complex biological systems.
3-(4-(Iodomethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine serves as a versatile photoreactive probe for covalent labeling of biomolecules. The diazirine ring enables efficient UV-induced formation of reactive carbene intermediates, while the iodomethyl group facilitates site-specific conjugation via nucleophilic substitution. Its trifluoromethyl substituent enhances metabolic stability and modulates lipophilicity, improving membrane permeability. This compound functions effectively in affinity labeling workflows and is compatible with standard purification methods.
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GHS Pictogram :
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GHS No : GHS02,GHS07
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Signal Word : Danger
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UN#: 1325
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Class : 4.1
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Packing Group : Ⅱ
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Hazard Statements : H228-H315-H319
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Precautionary Statements : P210-P240-P241-P264-P280-P302+P352-P362+P364-P370+P378
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Lot numbers can be found on the outside label of a product: