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CS-W001157 4
Total: USD 88.00

Benzyl 3-hydroxypiperidine-1-carboxylate

  • CAS No. 95798-22-4

  • Cat. No. CS-W003119
  • Purity≥95%
  • MDL No.MFCD03839903

*For research and further manufacturing use only, not for direct human use.

Benzyl 3-hydroxypiperidine-1-carboxylate|CS-W003119

Structure of 95798-22-4

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General Information

  • CAS No. 95798-22-4
  • Cat. No. CS-W003119
  • Purity ≥95%
  • MDL No. MFCD03839903
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₇NO₃
  • Molecular Weight 235.28
  • Synonym(s) 1-BENZYLOXYCARBONYL-3-HYDROXYPIPERIDINE
  • SMILES OC1CCCN(C1)C(=O)OCc1ccccc1

Description

Benzyl 3-hydroxypiperidine-1-carboxylate features a hydroxylated piperidine core with a benzyl ester handle, enabling straightforward deprotection under mild conditions. This scaffold integrates readily into medicinal chemistry libraries, offering a polar, flexible moiety for targeted molecular design.

Application

Benzyl 3-hydroxypiperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds. The hydroxyl group facilitates selective derivatization, while the benzyl carbamate protects the nitrogen under standard conditions. It functions as a key intermediate in the synthesis of bioactive molecules, offering excellent stability, ease of purification, and compatibility with diverse coupling and reduction protocols.

Synthesis

  • Route1
    • In-stock
      Piperidin-3-ol hydrochloride|CS-D1393
      64051-79-2
    • null|null
      501-53-1
    • ~98%
    • In-stock
      Benzyl 3-hydroxypiperidine-1-carboxylate|CS-W003119
      95798-22-4

    References

    • YM BIOSCIENCES AUSTRALIA PTY LTD; BURNS, Christopher John Patent: WO2014/32 A1, 2014 ; Location in patent: Page/Page column 44; 45 ;
  • Route2
    • 3-Hydroxypiperidine|CS-0653435
      6859-99-0
    • null|null
      501-53-1
    • ~97%
    • In-stock
      Benzyl 3-hydroxypiperidine-1-carboxylate|CS-W003119
      95798-22-4

    References

    • Kikuchi, Haruhisa; Yamamoto, Keisuke; Horoiwa, Seiko; Hirai, Shingo; Kasahara, Ryota; Hariguchi, Norimitsu; Matsumoto, Makoto; Oshima, Yoshiteru Journal of Medicinal Chemistry, 2006 , vol. 49, # 15 p. 4698 - 4706
  • Route3
    • In-stock
      Piperidin-3-ol hydrochloride|CS-D1393
      64051-79-2
    • null|null
      1885-14-9
    • ~%
    • In-stock
      Benzyl 3-hydroxypiperidine-1-carboxylate|CS-W003119
      95798-22-4

    References

    • US5753659 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   1.7799
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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