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Structure of 97608-50-9
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4-Chloro-3-(trifluoromethoxy)aniline features a trifluoromethoxy group that enhances electron-withdrawing character and metabolic stability, while the chlorine substituent provides a handle for further functionalization. This aniline derivative exhibits favorable solubility in common organic solvents and maintains bench-stable integrity under standard handling conditions.
4-Chloro-3-(trifluoromethoxy)aniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation into heterocyclic scaffolds via standard coupling reactions. Its ortho-chloro group facilitates palladium-catalyzed cross-couplings, while the trifluoromethoxy substituent enhances metabolic stability and modulates lipophilicity. The compound exhibits good bench stability and is readily purified by recrystallization or column chromatography, supporting efficient integration into multi-step synthetic sequences.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302+H312-H315-H319-H331-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: