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CS-W001157 4
Total: USD 88.00

4-Oxo-2-azetidinecarboxylic acid

  • CAS No. 98019-65-9

  • Cat. No. CS-W019929
  • Purity≥97%
  • MDL No.MFCD00798160
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Oxo-2-azetidinecarboxylic acid|CS-W019929

Structure of 98019-65-9

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Description

4-Oxo-2-azetidinecarboxylic acid is a strained, electron-deficient β-lactam derivative featuring a ketone at the C4 position and a carboxylic acid at C2. This unique combination enables direct incorporation into peptide macrocycles and bioconjugation workflows, offering enhanced reactivity in amide bond formation under mild conditions. The molecule exhibits bench-stable handling characteristics with high functional group tolerance.

Application

4-Oxo-2-azetidinecarboxylic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive β-lactam derivatives and constrained peptide mimetics. Its strained azetidine ring facilitates efficient cyclization reactions and exhibits favorable reactivity in amide bond formation. The ketone functionality provides a handle for selective transformations, while the carboxylic acid group supports direct derivatization or salt formation, enhancing solubility and purification. This compound offers robust bench stability and compatibility with standard synthetic protocols, making it well-suited for iterative library synthesis and process development.

General Information

  • CAS No. 98019-65-9
  • Cat. No. CS-W019929
  • Purity ≥97%
  • MDL No. MFCD00798160
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅NO₃
  • Molecular Weight 115.09
  • Synonym(s) 4-OXOAZETIDINE-2-CARBOXYLIC ACID
  • SMILES O=C(C(C1)NC1=O)O

Computational Chemistry Data

  • TPSA   66.4
  • LogP   -1.0405
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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