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Structure of 98019-65-9
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4-Oxo-2-azetidinecarboxylic acid is a strained, electron-deficient β-lactam derivative featuring a ketone at the C4 position and a carboxylic acid at C2. This unique combination enables direct incorporation into peptide macrocycles and bioconjugation workflows, offering enhanced reactivity in amide bond formation under mild conditions. The molecule exhibits bench-stable handling characteristics with high functional group tolerance.
4-Oxo-2-azetidinecarboxylic acid serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive β-lactam derivatives and constrained peptide mimetics. Its strained azetidine ring facilitates efficient cyclization reactions and exhibits favorable reactivity in amide bond formation. The ketone functionality provides a handle for selective transformations, while the carboxylic acid group supports direct derivatization or salt formation, enhancing solubility and purification. This compound offers robust bench stability and compatibility with standard synthetic protocols, making it well-suited for iterative library synthesis and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: