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CS-W001157 4
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tert-Butyl N-(3-hydroxypropyl)-N-methylcarbamate

  • CAS No. 98642-44-5

  • Cat. No. CS-0039237
  • Molecule weight189.26
  • Purity≥98%
  • MDL No.MFCD09751790

*For research and further manufacturing use only, not for direct human use.

tert-Butyl N-(3-hydroxypropyl)-N-methylcarbamate|CS-0039237

Structure of 98642-44-5

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General Information

  • CAS No. 98642-44-5
  • Cat. No. CS-0039237
  • Purity ≥98%
  • MDL No. MFCD09751790
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₉NO₃
  • Molecular Weight 189.26
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N(C)CCCO

Description

tert-Butyl N-(3-hydroxypropyl)-N-methylcarbamate features a hydroxyl-bearing aliphatic chain flanked by a tert-butyl carbamate and methylated nitrogen, offering enhanced solubility and stability in polar solvents. This structure enables efficient incorporation into peptide-coupling workflows and protected amine derivatization under standard conditions.

Application

tert-Butyl N-(3-hydroxypropyl)-N-methylcarbamate serves as a versatile, bench-stable protecting group for primary amines, enabling selective derivatization in complex molecule synthesis. The carbamate functionality tolerates a broad range of reaction conditions and facilitates orthogonal deprotection under mild acidic conditions. Its hydroxyl group allows further functionalization via esterification or ether formation, making it valuable in the construction of heterocyclic scaffolds and medicinal chemistry intermediates.

Synthesis

  • Route1
    • null|null
      114326-13-5
    • ~95%
    • In-stock
      tert-Butyl N-(3-hydroxypropyl)-N-methylcarbamate|CS-0039237
      98642-44-5

    References

    • Journal of Organic Chemistry, , vol. 53, # 10 p. 2226 - 2232
  • Route2

    References

    • Tetrahedron Letters, , vol. 49, # 16 p. 2527 - 2532
  • Route3

    References

    • Tetrahedron Letters, , vol. 46, # 42 p. 7147 - 7149

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   1.2357
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   3

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