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CS-W001157 4
Total: USD 88.00

2-Cyano-3-cyclopropylacrylic acid

  • CAS No. 98895-60-4

  • Cat. No. CS-0188494
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Cyano-3-cyclopropylacrylic acid|CS-0188494

Structure of 98895-60-4

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General Information

  • CAS No. 98895-60-4
  • Cat. No. CS-0188494
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₂
  • Molecular Weight 137.14
  • Synonym(s) 2-cyano-3-cyclopropylprop-2-enoic acid
  • SMILES N#CC(=CC1CC1)C(=O)O

Description

2-Cyano-3-cyclopropylacrylic acid features a conjugated cyano-acrylic acid scaffold with a cyclopropyl substituent that imparts steric and electronic modulation. This structure enables direct incorporation into Michael acceptor frameworks, facilitating efficient covalent coupling in synthetic peptide modifications and bioconjugation workflows under standard conditions.

Application

2-Cyano-3-cyclopropylacrylic acid serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized heterocycles and bioactive scaffolds. Its conjugated nitrile and acrylic acid functionalities facilitate Michael additions, cycloadditions, and decarboxylative transformations under mild conditions. The cyclopropyl group imparts structural rigidity and enhanced metabolic stability, making it valuable in medicinal chemistry lead optimization. Bench-stable and readily purified by recrystallization, it functions reliably in standard coupling and derivatization protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   61.09
  • LogP   0.93098
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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