2-Bromo-5-cyclopropylpyrazine

CAS No. 1086382-78-6
Cat. No. CS-D0132
Purity≥98%
MDL No.MFCD11223431

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

2-Bromo-5-cyclopropylpyrazine features a cyclopropyl group that enhances lipophilicity and metabolic stability, while the bromine substituent enables facile cross-coupling reactions. This scaffold integrates readily into diverse heterocyclic architectures under standard conditions, offering a robust platform for medicinal chemistry and materials synthesis.

Application

2-Bromo-5-cyclopropylpyrazine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to construct biaryl and heteroaryl scaffolds. The bromine atom facilitates efficient functionalization under standard Suzuki, Stille, or Negishi conditions, while the cyclopropyl group enhances metabolic stability and modulates lipophilicity. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for iterative synthesis of complex heterocyclic systems.

General Information

CAS No. 1086382-78-6
Cat. No. CS-D0132
Purity ≥98%
MDL No. MFCD11223431
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇BrN₂
Molecular Weight 199.05
Synonym(s) None
SMILES BrC1=NC=C(C2CC2)N=C1

Computational Chemistry Data

TPSA 25.78
LogP 2.1165
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazine compounds

Building Blocks Skeleton Fatty ring compounds Cyclopropane compounds

Key Words

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2-Bromo-5-cyclopropylpyrazine

CAS No. 1086382-78-6

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