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CS-W001157 4
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3-Ethynyltetrahydrofuran

  • CAS No. 1100987-19-6

  • Cat. No. CS-0170800
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Ethynyltetrahydrofuran|CS-0170800

Structure of 1100987-19-6

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General Information

  • CAS No. 1100987-19-6
  • Cat. No. CS-0170800
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈O
  • Molecular Weight 96.13
  • Synonym(s) 3-ethynyloxolane
  • SMILES C#CC1CCOC1

Description

3-Ethynyltetrahydrofuran delivers a reactive alkyne handle within a stable, oxygen-rich heterocyclic framework. This bench-stable reagent integrates readily into copper-catalyzed click chemistry protocols and supports efficient coupling with azides under mild conditions. The tetrahydrofuran ring enhances solubility in polar organic solvents while the terminal alkyne enables precise molecular assembly in synthetic and medicinal chemistry applications.

Application

3-Ethynyltetrahydrofuran serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized heterocycles via transition-metal-catalyzed coupling reactions. Its terminal alkyne group exhibits excellent stability under standard bench conditions and demonstrates broad compatibility with palladium- and copper-mediated transformations, facilitating rapid diversification for medicinal chemistry and materials applications.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅱ
Hazard Statements : H225-H315-H319-H335
Precautionary Statements : P210-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   0.6561
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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