2-Boc-2-Azaspiro[3.3]heptane-OH

CAS No. 1147557-97-8
Cat. No. CS-D0139
Purity≥97%
MDL No.MFCD15071431

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Type	HazMat Fee
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FedEx Limited Quantities Ground	$0.00
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2-Boc-2-Azaspiro[3.3]heptane-OH|CS-D0139

Structure of 1147557-97-8

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Description

tert-Butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate is a sterically encumbered spirocyclic scaffold featuring a hydroxyl group at the 6-position and a bench-stable tert-butyl ester. This configuration enables direct functionalization at the hydroxyl site while maintaining structural rigidity for use in medicinal chemistry and asymmetric synthesis.

Application

tert-Butyl 6-hydroxy-2-azaspiro[3.3]heptane-2-carboxylate serves as a versatile spirocyclic building block for the synthesis of nitrogen-containing heterocycles, particularly in medicinal chemistry and natural product synthesis. The pendant hydroxyl group enables selective derivatization via esterification or ether formation, while the tert-butyl carbamate offers orthogonal protection for amine functionalization. Its rigid spirocyclic framework provides conformational constraint, facilitating stereocontrolled transformations. The compound exhibits excellent bench stability and is compatible with standard purification methods.

General Information

CAS No. 1147557-97-8
Cat. No. CS-D0139
Purity ≥97%
MDL No. MFCD15071431
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₉NO₃
Molecular Weight 213.28
Synonym(s) None
SMILES O=C(OC(C)(C)C)N1CC2(C1)CC(O)C2

Computational Chemistry Data

TPSA 49.77
LogP 1.3782
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Fatty ring compounds Cyclobutane compounds

Building Blocks Skeleton Spirol Rings compounds

Drug Discovery Cancer KRAS

Key Words

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2-Boc-2-Azaspiro[3.3]heptane-OH

CAS No. 1147557-97-8

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