3-Bromo-2-chloro-6-(trifluoromethyl)pyridine

CAS No. 1159512-34-1
Cat. No. CS-0041348
Purity≥98%
MDL No.MFCD11226615

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3-Bromo-2-chloro-6-(trifluoromethyl)pyridine|CS-0041348

Structure of 1159512-34-1

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Description

3-Bromo-2-chloro-6-(trifluoromethyl)pyridine is a halogenated pyridine derivative featuring orthogonal reactivity at bromo and chloro sites. The trifluoromethyl group imparts enhanced electron-withdrawing character and metabolic stability, enabling efficient coupling in cross-coupling reactions. This scaffold serves as a key building block for bioactive heterocycles in medicinal chemistry and agrochemical development.

Application

3-Bromo-2-chloro-6-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The ortho-chloro and bromo substituents allow for sequential functionalization, while the trifluoromethyl group enhances metabolic stability and lipophilicity. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of complex heterocyclic scaffolds relevant to pharmaceutical development.

General Information

CAS No. 1159512-34-1
Cat. No. CS-0041348
Purity ≥98%
MDL No. MFCD11226615
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂BrClF₃N
Molecular Weight 260.44
Synonym(s) 5-Bromo-6-chloro-alpha,alpha,alpha-trifluoro-2-picoline
SMILES FC(C1=CC=C(Br)C(Cl)=N1)(F)F

Computational Chemistry Data

TPSA 12.89
LogP 3.5163
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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3-Bromo-2-chloro-6-(trifluoromethyl)pyridine

CAS No. 1159512-34-1

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