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(3S,4S)-tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate

  • CAS No. 1174020-44-0

  • Cat. No. CS-0058579
  • Purity≥95%
  • MDL No.MFCD18791210

*For research and further manufacturing use only, not for direct human use.

(3S,4S)-tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate|CS-0058579

Structure of 1174020-44-0

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General Information

  • CAS No. 1174020-44-0
  • Cat. No. CS-0058579
  • Purity ≥95%
  • MDL No. MFCD18791210
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₈FNO₃
  • Molecular Weight 219.25
  • Synonym(s) tert-butyl (3S,4S)-3-fluoro-4-hydroxypiperidine-1-carboxylate
  • SMILES F[C@@H]1[C@@H](O)CCN(C(OC(C)(C)C)=O)C1

Description

This chiral piperidine derivative features a fluoro group at the 3-position and a hydroxyl moiety at the 4-position, stabilized by a tert-butyl carbamate protecting group. The stereochemistry at C3 and C4 imparts distinct conformational control, enabling selective incorporation into complex molecular architectures. Bench-stable and moisture-tolerant, it serves as a key building block for bioactive molecule synthesis.

Application

(3S,4S)-tert-Butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate serves as a stereochemically defined building block for fluorinated piperidine scaffolds. The tert-butoxycarbonyl (Boc) group enables convenient protection and orthogonal deprotection, while the C3-fluoro and C4-hydroxy functionalities provide distinct sites for derivatization. This compound exhibits bench stability and facilitates selective functionalization in medicinal chemistry campaigns targeting bioactive heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   1.3262
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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