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Ethyl 2-(6-aminopyridin-3-yl)acetate

  • CAS No. 1174229-72-1

  • Cat. No. CS-0042619
  • Molecule weight180.20
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Ethyl 2-(6-aminopyridin-3-yl)acetate|CS-0042619

Structure of 1174229-72-1

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General Information

  • CAS No. 1174229-72-1
  • Cat. No. CS-0042619
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂N₂O₂
  • Molecular Weight 180.20
  • Synonym(s) ethyl (6-aminopyridin-3-yl)acetate
  • SMILES O=C(OCC)CC1=CC=C(N)N=C1

Description

Ethyl 2-(6-aminopyridin-3-yl)acetate features a pyridine core functionalized with an amino group at the 6-position and an acetyl ester side chain, enabling direct incorporation into heterocyclic scaffolds. This bench-stable intermediate supports efficient derivatization in medicinal chemistry campaigns targeting kinase inhibitors and bioactive nitrogen-containing compounds.

Application

Ethyl 2-(6-aminopyridin-3-yl)acetate serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based pharmacophores. The pendant amino group facilitates direct derivatization via acylation, alkylation, or coupling reactions, while the ester functionality supports hydrolysis or transformation into amides and carboxylic acids. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for iterative synthesis of heterocyclic scaffolds relevant to kinase inhibitors and other bioactive molecules.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   65.21
  • LogP   0.7694
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   3

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