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CS-W001157 4
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2-(5-Bromopyridin-2-yl)propan-2-amine

  • CAS No. 1211518-99-8

  • Cat. No. CS-0368766
  • Molecule weight215.09
  • Purity≥96%
  • MDL No.MFCD18259150

*For research and further manufacturing use only, not for direct human use.

2-(5-Bromopyridin-2-yl)propan-2-amine|CS-0368766

Structure of 1211518-99-8

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General Information

  • CAS No. 1211518-99-8
  • Cat. No. CS-0368766
  • Purity ≥96%
  • MDL No. MFCD18259150
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₁BrN₂
  • Molecular Weight 215.09
  • Synonym(s) 3-Bromo-6-(2-Aminopropan-2-yl)pyridine
  • SMILES BrC1=CN=C(C(C)(C)N)C=C1

Description

2-(5-Bromopyridin-2-yl)propan-2-amine features a sterically hindered tertiary amine linked to a brominated pyridine ring, enabling efficient coupling in transition-metal-catalyzed transformations. The electron-deficient pyridine moiety enhances reactivity in cross-coupling processes, while the bulky isopropyl group improves solubility and stability under standard conditions.

Application

2-(5-Bromopyridin-2-yl)propan-2-amine serves as a versatile building block for C–N coupling reactions, enabling efficient construction of biaryl and heterocyclic scaffolds. Its tertiary amine functionality offers enhanced solubility and stability compared to primary analogs, while the bromopyridine moiety facilitates palladium-catalyzed cross-coupling transformations. The bulky tert-butyl group imparts steric protection and improves purification efficiency, making it ideal for iterative synthesis in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   2.0379
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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