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CS-W001157 4
Total: USD 88.00

2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid

  • CAS No. 1211526-53-2

  • Cat. No. CS-D0153
  • Purity≥97%
  • MDL No.MFCD17016194
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid|CS-D0153

Structure of 1211526-53-2

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Description

This spirocyclic diacid derivative features a protected amine and carboxylic acid group, enabling direct incorporation into peptide synthesis. The tert-butoxycarbonyl moiety ensures stability during handling and reaction sequences. The rigid spirocyclic core provides defined stereochemistry and conformational control.

Application

2-(tert-Butoxycarbonyl)-2-azaspiro[3.3]heptane-6-carboxylic acid serves as a versatile spirocyclic building block for the synthesis of nitrogen-containing heterocycles. The Boc-protected amine and carboxylic acid functionalities enable orthogonal functionalization, facilitating efficient peptide coupling and reductive amination workflows. Its rigid spirocyclic core enhances conformational control in medicinal chemistry applications, while the tert-butyl carbamate group offers excellent bench stability and ease of removal under mild acidic conditions.

General Information

  • CAS No. 1211526-53-2
  • Cat. No. CS-D0153
  • Purity ≥97%
  • MDL No. MFCD17016194
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₉NO₄
  • Molecular Weight 241.29
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)N1CC2(C1)CC(C(=O)O)C2

Computational Chemistry Data

  • TPSA   66.84
  • LogP   1.7181
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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